Human LMNA / Lamin A+C

Rabbit

Human, Mouse, Rat, Bovine, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)

Bat, Dog, Xenopus (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide (RNKSNEDQSMGNWQI, aa455-469 of UniProt P02545) was used as the immunogen for this Lamin A/C antibody (100% homologous in human, mouse and rat). Percent identity by BLAST analysis: Human, Mouse, Rat, Sheep, Bovine, Hamster, Elephant, Rabbit, Horse, Pig, Guinea pig (100%); Ferret, Cat, Bat, Opossum, Zebra finch, Xenopus, Dog (93%); Chicken (80%).

aa455-469

Human LMNA / Lamin A+C

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• ICC (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A, B and C. The Lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Protein deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P02545 NCBI: NM_005572 NP_005563.1