Target
Human LF / LTF / Lactoferrin
Synonyms
LTF | GIG12 | Growth-inhibiting protein 12 | HLF2 | Lactotransferrin | Lactoferrin | LF | Neutrophil lactoferrin | Talalactoferrin
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Purified lactoferrin from human milk.
Specificity
Recognizes human lactoferrin, a 78kD globular protein found in body secretions such as milk and saliva and is a member of the transferrin family proteins. Transferrins control the level of free iron in the body, by binding and transporting iron. Lactoferrin does not appear to have a transporting function, instead it has antimicrobial activity, by keeping the levels of iron in body fluids low and thus preventing microbes from acquiring iron. Removing free iron from body fluids and inflamed areas also serve to protect against the damaging effects of free radicals. Lactoferrin is used as a therapeutic and prophylactic treatment of various illnesses, such as cancers and intestinal illnesses. Does not cross-react with human transferrins or other serum proteins.