Target
Human KLK6 / Kallikrein 6
Synonyms
KLK6 | Bssp | HK6 | Kallikrein-related peptidase 6 | Kallikrein 6 (neurosin, zyme) | Neurosin | Protease, serine, 18 | Protease M | PRSS9 | Serine protease 9 | Zyme | Serine protease 18 | Kallikrein 6 | Kallikrein-6 | PRSS18 | SP59
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
E. coli-derived human Kallikrein 6 recombinant protein (Position: L22-K244).
Specificity
In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.