Target
Human IPAF / NLRC4
Synonyms
NLRC4 | CARD12 | CLANA | CLANB | CLANC | CLAND | CLAN | CLR2.1 | Clan protein | CLAN1 | Ice protease-activating factor | NOD-like receptor C4 | ICE-protease activating factor | IPAF
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Purification
Immunogen affinity purified
Immunogen
A synthetic peptide corresponding to a sequence at the C-Terminus of human CARD12 (838-874 aa KILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDR), different from the related mouse sequence by five amino acids, and from the related rat sequence by seven amino acids.
Specificity
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.