Human IL6ST / CD130 / gp130

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

B-T2

Unconjugated

Ion exchange chromatography

Unmodified

Natural soluble gp130 receptor.

Recognizes soluble and membrane bound gp130 receptor, also known as CD130, Interleukin-6 receptor subunit beta, Oncostatin-M receptor subunit alpha or Interleukin-6 signal transducer. CD130 is a 918 amino acid, ~130 kD single pass type-1 transmembrane glycoprotein containing a single and multiple domains. CD130 can be cleaved to form a monomeric soluble ~100 kD form of the receptor detectable in plasma and other biologic fluids where it acts as an IL-6 antagonist. Binds to an epitope dependent at least partially on the presence of the Ig-like domain. Has been reported to block receptor activity and inhibit IL-6 induced proliferation of XG1 cells and IL-27 mediated proliferation of naive CD4+ T cells,.

• Flow Cytometry
• ELISA

Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P40189 NCBI: NM_002184 NP_002175.2