Human DDR2

Rabbit

Human, Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated. Also available conjugated with HRP, FITC, Biotin.

Protein G purified

Unmodified

Recombinant Human Discoidin domain-containing receptor 2 protein (447-540AA)

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

• IHC
• IHC - Paraffin (10 µg/ml)
• Immunofluorescence (1:50 - 1:200)
• Western blot (1:500 - 1:5000)
• ELISA

PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.

Short term: store at -20°C. Long term: store at -80°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q16832 NCBI: NM_006182 NP_006173.2