Target
Human HTRA2 / OMI
Synonyms
HTRA2 | HtrA-like serine protease | OMI | PARK13 | Protease, serine, 25 | PRSS25 | Serine protease 25 | HtrA serine peptidase 2 | Serine proteinase OMI
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Serine protease HTRA2, mitochondrial protein (334-458AA)
Specificity
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.