Target
Human HSD3B1
Synonyms
HSD3B1 | 3BETAHSD | 3-beta-HSD I | 3BH | HSD3B | HSDB3A | HSDB3 | Steroid Delta-isomerase | Trophoblast antigen FDO161G | Progesterone reductase | SDR11E1
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 protein (127-267AA)
Specificity
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone.