Target
Human HLA-G
Synonyms
HLA-G | HLAG | HLA-6.0 | MHC class I antigen G | HLA G antigen
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant human HLA-G refolded with beta 2 microglobulin.
Specificity
Recognizes human HLA-G, a non-classical major histocompatibility complex (MHC) molecule. HLA-G expression is restricted to trophoblast cells and some medullary thymic epithelial cells. Several isoforms of the HLA-G molecule exist, which include the membrane bound isoforms HLA-G1-G4 and soluble isoforms HLA-G5-G7. Clone MEM-G/Recognizes surface expressed native HLA-G1, when associated with beta 2 microglobulin, but does not recognize the isoforms HLA-G2, G3 and G4. Clone MEM-G/9 has also been reported to recognize the soluble isoform HLA-G5. Reactivity in flow cytometry is assessed by staining of HLA-G transfected cells.