Target
Human HLA-E
Synonyms
HLA-E | EA2.1 | HLAE | MHC HLA-E alpha-2.1 | MHC HLA-E alpha-1 | EA1.2 | HLA-6.2 | MHC class I antigen E | QA1
Reactivity
Human
(tested or 100% immunogen sequence identity)
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Immunogen
Bacterially expressed recombinant HLA-E refolded with beta2-microglobulin and peptide
Specificity
The antibody MEM-E/08 recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that antibody is remarkably specific for HLA-E, only with weak cross-reactivity with following classical MHC Class I molecules (MHC Class Ia): HLA-A24, -B7, -B27, -B51, -B54, -C7.