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GPR68 / OGR1
G protein-coupled receptor 68
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.
| Gene Name: | G protein-coupled receptor 68 |
| Family/Subfamily: | GPCR , Lysophospholipid/Lysosphingolipid |
| Synonyms: | GPR68, Brgrb, G protein-coupled receptor 68, G-protein coupled receptor 68, OGR1, Brgr1, GPR12A, OGR-1 |
| Target Sequences: | NM_003485 NP_003476.3 Q15743 |
Publications (4)
1
Proton-sensing G-protein-coupled receptors. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Nature. 2003 425:93-8. (IHC; Rat)
[PubMed:12955148]
Related Antibodies: LS-A1194.
2
Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:2643-8. (Rat)
[PubMed:15695591]
[PMC:PMC548977]
Related Antibodies: LS-A1194.
3
Expression of and role for ovarian cancer G-protein coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A and Odgren PR. The Journal of biological chemistry. 2006 281:23598-605. (ICC; Rat)
[PubMed:16787916]
Related Antibodies: LS-A1194.
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GPR68 / OGR1
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aa200-225
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aa281-330
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(26)
Yes
(1)
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(1)
Neuroscience
GPR68 / OGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Mouse, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, ICC, IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rat, Human, Monkey
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Horse, Bat, Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$395
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rabbit, Mouse, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$395
Fast Shipping
GPR68 / OGR1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rat, Human
IHC-P
Unconjugated
50 µg/$395
GPR68 / OGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Rat, Human
ICC, IF, WB
Unconjugated
30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$287; 100 µl/$431
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa217-266) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa217-266) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Hamster, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa217-266) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Hamster, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa217-266) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Hamster, Chimpanzee, Orangutan, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
GPR68 / OGR1 Rabbit anti-Human Polyclonal (250-330 aa, C-terminal) Antibody
Mouse, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa281-330) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
GPR68 / OGR1 Rabbit anti-Mouse Polyclonal (aa200-225) Antibody
Mouse
WB
Unconjugated
400 µl/$393
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
GPR68 / OGR1 Rabbit anti-Human Polyclonal (Arg214) Antibody
Mouse, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa153-202) Antibody
Human
WB
Unconjugated
100 µl/$424
GPR68 / OGR1 Rabbit anti-Human Polyclonal (aa153-202) (Biotin) Antibody
Human, Chimpanzee, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$469
GPR68 / OGR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
50 µl/$305; 100 µl/$357
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