order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
order histories, retained contact details for faster checkout, review submissions, and special promotions.
GABBR2 / GABA B Receptor 2
gamma-aminobutyric acid (GABA) B receptor, 2
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
| Gene Name: | gamma-aminobutyric acid (GABA) B receptor, 2 |
| Family/Subfamily: | GPCR , GABA(B) |
| Synonyms: | GABBR2, G protein-coupled receptor 51, GABA(B2), GABA-B receptor 2, Gaba-b receptor r2, GABA-BR2, Gabab-receptor subunit 2, GABA(B)R2, GABA-B receptor, R2 subunit, GABA-B-R2, GABAB receptor-2, GPRC3B, Gb2, HRIHFB2099, G-protein coupled receptor 51, GPR51, HG20, GABA B Receptor 2, GABA-B2, GABAB2, GABABR2, Gbr2 |
| Target Sequences: | NM_005458 NP_005449.5 O75899 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
