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Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for gamete recognition and fertilization. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Gene Name: | IZUMO1 Receptor, JUNO |
Synonyms: | FR4, FOLR4, Folate receptor 4, FR-delta, Probable folate receptor delta, Folbp3, IZUMO1R, JUNO |
Target Sequences: | NP_001073955.1 A6ND01 |
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