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FOS / c-FOS
FBJ murine osteosarcoma viral oncogene homolog
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
| Gene Name: | FBJ murine osteosarcoma viral oncogene homolog |
| Synonyms: | FOS, Activator protein 1, AP-1, Cellular oncogene c-fos, Cellular oncogene fos, Proto-oncogene c-Fos, v-fos, C-FOS, G0s7, p55 |
| Target Sequences: | NM_005252 NP_005243.1 P01100 |
Publications (3)
1
Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study. Koh WU, Choi SS, Lee JH, Lee SH, Lee SK, Lee YK, Leem JG, Song JG, Shin JW. BMC complementary and alternative medicine. 2014 14:431. (IHC; Human)
[Full Text Article]
[PubMed:25366818]
[PMC:PMC4246472]
Related Antibodies: LS-C93966.
2
Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?. Frasch MG, Szynkaruk M, Prout AP, Nygard K, Cao M, Veldhuizen R, Hammond R, Richardson BS. Journal of neuroinflammation. 2016 13:103. (WB; Human)
[Full Text Article]
[PubMed:27165310]
[PMC:PMC4894374]
Related Antibodies: LS-C77393.
3
c-FOS drives reversible basal to squamous cell carcinoma transition. François Kuonen, Nancy Yanzhe Li, Daniel Haensel, Tiffany Patel, Sadhana Gaddam, Laura Yerly, Kerri Rieger, Sumaira Aasi, Anthony E Oro. Cell reports. 2021 October;37:109774. [Full Text Article]
[PubMed:34610301]
[PMC:PMC8515919]
Related Antibodies: LS-B14369.
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(62)
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(222)
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(3)
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(4)
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Neuroscience
FOS / c-FOS Goat anti-Human Polyclonal (aa283-295) Antibody
Dog, Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
FOS / c-FOS Mouse anti-Human Monoclonal (1H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
FOS / c-FOS Mouse anti-Human Monoclonal (aa128-152) (2G9C3) Antibody
Chicken, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IF, WB
Unconjugated
100 µg/$762
Neuroscience
FOS / c-FOS Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
FOS / c-FOS Sheep anti-Human Polyclonal (aa300-380) Antibody
Mouse, Rat, Human
WB
Unconjugated
500 µg/$393
FOS / c-FOS Mouse anti-Human Monoclonal (554C1a) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
FOS / c-FOS Sheep anti-Human Polyclonal (aa4-17) Antibody
Rat, Human
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
500 µg/$832
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
FOS / c-FOS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$341
FOS / c-FOS Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
FOS / c-FOS Rabbit anti-Human Polyclonal (aa201-250) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
FOS / c-FOS Mouse anti-Bovine Monoclonal Antibody
Mouse, Bovine, Rat, Human
IF, IHC, WB
Unconjugated
100 µl/$469
FOS / c-FOS Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
FOS / c-FOS Rabbit anti-Human Polyclonal (pS362) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$315
FOS / c-FOS Mouse anti-Human Monoclonal (OTI3B8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
FOS / c-FOS Mouse anti-Human Monoclonal (OTI2D2) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$434
FOS / c-FOS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$460
FOS / c-FOS Mouse anti-Human Monoclonal (2G2) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
FOS / c-FOS Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
FOS / c-FOS Rabbit anti-Human Polyclonal (pSer362) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
FOS / c-FOS Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P
Unconjugated
100 µl/$412
FOS / c-FOS Mouse anti-Human Monoclonal (2G2) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µl/$503
FOS / c-FOS Mouse anti-Human Monoclonal (Carrier-free) (UMAB221) Antibody
Human
IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
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