Human Fibrin Degradation Product D-Dimer

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

DD5

Unconjugated

Affinity purified

Unmodified

Homogenized fibrin clot.

Recognizes human D-dimer and shows low cross-reactivity with fibrinogen (D-monomer). D-dimers are the principle degradation products of cross-linked fibrin, released into the bloodstream following the digestion of fibrin clots (thrombus) by the enzyme plasmin, and thus measurement of the level of D-dimer in plasma, can be used as an indication of thrombotic disorders. Conditions in which levels of D-dimer are elevated include deep vein thrombosis (DVT), venous thromboembolism (VTE), cardiovascular disease and disseminated intravascular coagulation (DIC), a possible acute condition arising from surgical operations, septic shock and liver disease. Can be used as the detection antibody in ELISA for the detection of D-dimer in human plasma. Plasma samples must be diluted with 10 mM Tris-HCl buffer, pH7.5, containing 1 M NaCl (final concentration in sample >0.5 M) and 0.1% Tween 20.

• Western blot
• ELISA

• IHC - Paraffin

ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with clone DD1 (product code LS-C58035), for the detection of D-dimer in human plasma. Plasma samples must be diluted with 10 mM Tris-HCl buffer, pH7.5, containing 1 M NaCl (final concentration in sample >0.5 M) and 0.1% Tween 20.WESTERN BLOT: Please note that non-reducing conditions are required for detection of the D-dimer.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

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