Target
Human FADS1
Synonyms
FADS1 | D5D | Delta-5 fatty acid desaturase | Delta(5) fatty acid desaturase | Delta-5 desaturase | Fatty acid desaturase 1 | FADSD5 | LLCDL1 | Delta(5) desaturase | TU12
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Recombinant Human Fatty acid desaturase 1 protein (1-121AA)
Specificity
Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3), respectively.