Target
Human ERVWE1 / HERV / Syncytin
Synonyms
ERVW-1 | Env-W | Envelope polyprotein gPr73 | ERVWE1 | HERV-W-ENV | Envelope glycoprotein | Enverin | ENVW | HERV-7q Envelope protein | HERV-W Env glycoprotein | HERV-W envelope protein | HERVW | Syncytin A | Syncytin-1 | env | Envelope protein | HERV-7q | HERV-W | HERV7Q | HERVWENV | Syncytin
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Purification
Immunogen affinity purified
Immunogen
A synthetic peptide corresponding to a sequence at the C-Terminus of human ERVW-1(406-435 aa YYVNQSGIVTEKVKEIRDRIQRRAEELRNT).
Specificity
Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia. .