Rat EDNRB / Endothelin B Receptor

Sheep

Rat (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Affinity purified

Unmodified

Keyhole limpet hemocyanin (KLH) conjugated C-Terminus peptide KANDHGYDNFRSSNN corresponding to amino acids 424 to 437 of rat endothelin B receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Sheep, Goat, Hamster, Elephant, Panda, Cat, Bovine, Dog, Horse, Rabbit, Pig, Opossum, Zebra finch, Chicken, Platypus (93%); Lizard (87%).

aa424-437

Recognizes an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. AAR43 recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins. AAR43 is reported as suitable for use in immunocytochemistry on acetone fixed cells.

• IHC
• IHC - Paraffin (10 - 20 µg/ml)
• Immunofluorescence (10 - 20 µg/ml)
• Immunoprecipitation (20 - 40 µg/ml)

PBS, less than 0.1% Sodium Azide

Store at 4°C. Do not freeze. Store undiluted. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P24530 NCBI: NM_000115 NP_000106.1