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Catalog Number	Size	Price
LS-C502099-50	50 µg	$294
LS-C502099-100	100 µg	$360

Polyclonal Rabbit anti‑Human DTL / CDT2 Antibody (Biotin) LS‑C502099

Name: Anti-DTL / CDT2 Antibody | Rabbit anti-Human Polyclonal Biotin | LSBio
Brand: Lifespan BioSciences
SKU: LS-C502099-50
Price: 294.0000 USD
Availability: InStock

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Antibody:

DTL / CDT2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Application:

ELISA

Reactivity:

Human

Format:

Biotin, Unmodified

Other formats:

Unconjugated HRP FITC

$294

LS-C502099-50

Toll Free North America

(800) 227-6666

For Research Use Only

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Overview

Antibody:

DTL / CDT2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Application:

ELISA

Reactivity:

Human

Format:

Biotin, Unmodified

Other formats:

Unconjugated HRP FITC

Specifications

Description

CDT2 antibody LS-C502099 is a biotin-conjugated rabbit polyclonal antibody to human CDT2 (DTL). Validated for ELISA.

Target

Human DTL / CDT2

Synonyms

See All DTL / CDT2 Antibodies

Host

Rabbit

Reactivity

Human (tested or 100% immunogen sequence identity)

Clonality

IgG Polyclonal

Conjugations

Biotin. Also available Unconjugated or conjugated with HRP, FITC.

Purification

Protein G purified

Modifications

Unmodified

Immunogen

Recombinant Human Denticleless protein homolog protein (393-550AA)

Specificity

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613).

Applications