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Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.
Gene Name: | debranching RNA lariats 1 |
Synonyms: | DBR1, Lariat debranching enzyme, RNA lariat debranching enzyme |
Target Sequences: | NM_016216 NP_057300.2 Q9UK59 |
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