Human Complement C1q

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

3R9/2

Unconjugated

Protein A purified

Unmodified

Binds globular head domain of C1q, purified from human plasma.

Recognizes human complement component 1, q subcomponent (C1q), a 156kD secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

• IHC
• IHC - Frozen (1:500 - 1:1000)
• Immunofluorescence
• Western blot
• Flow Cytometry
• ELISA

Immunohistology: Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).

BBS, 0.09% Sodium Azide

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.