Human CDH3 / P-Cadherin

Rabbit

Human, Horse (tested or 100% immunogen sequence identity)

Mouse, Rat, Bat, Dog, Hamster, Sheep (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Amino acids 612-626 (QDTYDVHLSLSDHGN-human) were used as the immunogen for this P-Cadherin antibody. Percent identity by BLAST analysis: Human, Elephant, Horse (100%); Mouse, Rat, Sheep, Cat, Bat, Hamster, Dog (93%); Rabbit, Guinea pig (87%); Ferret, Bovine (80%).

aa612-626

Human CDH3 / P-Cadherin

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• ICC (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. P-Cadherin is a protein that in humans is encoded by the CDH3 gene. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P22223 NCBI: NM_001793 NP_001784.2