Target
Mouse CD68
Synonyms
CD68 | CD68 antigen | gp110 | SCARD1 | CD68 molecule | LAMP4 | Macrophage antigen CD68 | Macrosialin
Reactivity
Mouse
(tested or 100% immunogen sequence identity)
Conjugations
R. Phycoerythrin.
Also available
Unconjugated or conjugated with
Biotin,
FITC.
Immunogen
Purified Concanavalin A acceptor glycoprotein from P815 cell line.
Specificity
Macrosialin is a heavily glycosylated transmembrane protein of 87-115kD, which is specifically expressed by tissue macrophages, Langerhans cells and at low levels by dendritic cells. Macrosialin is the murine homologue of the human macrophage glycoprotein CD68, both are members of the lysosomal-associated membrane protein (LAMP) family which are located predominantly within the cells and can be detected by flow cytometry using cell permeabilization. The antibody does detect surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.