Target
Human CD300A
Synonyms
CD300A | CD300a antigen | CD300a molecule | CMRF35-like molecule 8 | CMRF35-H | CMRF35-H9 | CLM-8 | CMRF35H9 | IGSF12 | Inhibitory receptor protein 60 | IRC2 | IRC1 | NK inhibitory receptor | CMRF-35-H9 | CMRF-35H | CMRF35H | IRC1a | IRp60 | Leukocyte membrane antigen
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
Human HPB acute lymphoid leukaemia cell line.
Specificity
Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.