Target
Human CD22
Synonyms
CD22 | CD22 molecule | CD22 antigen | SIGLEC2 | SIGLEC-2 | T-cell surface antigen Leu-14 | B-cell receptor CD22 | BL-CAM
Reactivity
Human, Non-Human Primates
(tested or 100% immunogen sequence identity)
Conjugations
Unconjugated.
Also available conjugated with
Biotin.
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Immunogen
Raji Burkitt’s lymphoma cell line
Specificity
The antibody MEM-01 reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. The antibody MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E"; it does not cross-block antibodies RFB-4, CLB22/1 and CLB-BLy1.