Human CD1A

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

CBT6

Unconjugated

Purified

Unmodified

CBT6 is a mouse monoclonal IgG1 antibody derived by the fusion of NS0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a T-lymphocyte derived antigen.

The CBT6 antibody is directed against human CD1a and has been reported to cross react with mouse thymocytes.

• IHC
• IHC - Frozen
• ICC
• Flow Cytometry
• ELISA

CD1 molecules are 49kD type 1 membrane glycoproteins that contain a single Ig-like domain, which associate with beta-2 microglobulin to form a heterodimer. The CD1 glycoproteins function as antigen-presenting molecules for exogenous and endogenous lipids, glycolipids and lipopeptides to specialized T cells. The CD1 molecules show some sequence similarities to major histocompatibility (MHC) class I and class II molecules, but are not encoded by the MHC genes and are not significantly polymorphic. In humans, the CD1 genes encode five isoforms of CD1, namely CD1a-e, with each type reported to show a different pattern of expression on cells and within different tissues. CD1a, b and c belong to group 1 of the CD1 family and are expressed by dendritic cells, activated monocytes and other antigen-presenting cells. CD1a is also expressed by some malignancies of T cell lineage and is commonly used as a marker of dendritic cell populations.

PBS, 50% glycerol, 0.2% BSA, 0.02% sodium azide

Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P06126 NCBI: M28825 AAA51931.1