Human CASP4 / Caspase 4

Rabbit

Human (tested or 100% immunogen sequence identity)

Polyclonal

Unconjugated

Purified

Concentrated

A 16 AA peptide from human Caspase-4 N-Terminus

N-Terminus

PS 298 recognizes an epitope within the N-terminal region (NT) of Caspase-4, otherwise known as ICH-2. Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localization of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimer's disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis. PS 298 detects a band of approximately 34 kD in Ramos cell lysates (predicted precursor MWT 31 kD).

• IHC
• IHC - Paraffin
• Western blot

PBS, 0.02% Sodium Azide

Store at 2-8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P49662 NCBI: NM_001225 NP_001216.1