Target
Human ATM
Synonyms
ATM | A-T mutated | ATA | ATC | ATD | ATE | AT mutated | Ataxia telangiectasia | ATDC | Serine-protein kinase ATM | AT1 | Ataxia telangiectasia mutated | TEL1 | TELO1
Reactivity
Human
(tested or 100% immunogen sequence identity)
Immunogen
GST fusion protein expressed in E. coli corresponding to aa 2577-3056 of full-length ATM.
Specificity
Recognizes full-length ATM, a 370 kD nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.