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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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order histories, retained contact details for faster checkout, review submissions, and special promotions.
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| Catalog Number | Size | Price |
|---|---|---|
| LS-C501091-50 | 50 µg | $294 |
| LS-C501091-100 | 100 µg (2 mg/ml) | $360 |
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Polyclonal Rabbit anti‑Human ATG14 Antibody (IHC, IF) LS‑C501091
Polyclonal Rabbit anti‑Human ATG14 Antibody (IHC, IF) LS‑C501091
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
ATG14 antibody LS-C501091 is an unconjugated rabbit polyclonal antibody to human ATG14. Validated for ELISA, IF and IHC.
Target
Human ATG14
Synonyms
ATG14 | Autophagy related 14 | Beclin 1-Interacting protein | KIAA0831 | ATG14L | BARKOR
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human Beclin 1-associated autophagy-related key regulator protein (1-492AA)
Specificity
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Applications
- IHC
- Immunofluorescence
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ATG14
Publications (0)
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Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Source:
E. coli
Tag:
10His, N-terminus + Myc, C-terminus
Source:
E. coli
Tag:
His-GST
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/15/2024
Date Requested: 11/15/2024
