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VIL1 / Villin
villin 1
Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.
| Gene Name: | villin 1 |
| Synonyms: | VIL1, D2S1471, Villin, Villin 1, Villin-1, VIL |
| Target Sequences: | NM_007127 NP_009058.2 P09327 |
Publications (2)
1
Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Tissue engineering. Part A. 2018 July;4:1138-1147. [Full Text Article]
[PubMed:29383981]
[PMC:PMC6033308]
Related Antibodies: LS-C407669.
2
The Therapeutic Effect of Active Vitamin D Supplementation in Preventing the Progression of Diabetic Nephropathy in a Diabetic Mouse Model. Nakhoul Nakhoul, Tina Thawko, Evgeny Farber, Inbal Dahan, Hagar Tadmor, Rola Nakhoul, Anaam Hanut, Ghasan Salameh, Ibrahim Shagrawy, Farid Nakhoul. Journal of diabetes research. 2020 December;2020:7907605. [Full Text Article]
[PubMed:33294462]
[PMC:PMC7714593]
Related Antibodies: LS-C407669.
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(65)
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(51)
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(23)
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(1)
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(1)
aa770-799
(1)
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(64)
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(1)
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(2)
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(2)
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(5)
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(5)
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(4)
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(2)
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(3)
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(7)
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293T Cells
(1)
E. coli
(2)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(3)
VIL1 / Villin Rabbit anti-Human Polyclonal (aa770-799) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
VIL1 / Villin Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$605
VIL1 / Villin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
VIL1 / Villin Rabbit anti-Human Polyclonal (aa7-246) Antibody
Mouse, Rat, Human
ICC, IF, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
VIL1 / Villin Rabbit anti-Human Polyclonal (aa1-320) (APC) Antibody
Mouse, Pig, Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
VIL1 / Villin Rabbit anti-Human Polyclonal (aa180-207) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
VIL1 / Villin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IF, WB
Unconjugated
100 µl/$688
Cancer Pathology
Cancer
VIL1 / Villin Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
VIL1 / Villin Mouse anti-Human Monoclonal (CWWB1) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.05 ml/$460
VIL1 / Villin Mouse anti-Human Monoclonal (3E5G11) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
VIL1 / Villin Mouse anti-Human Monoclonal (VIL1/1314) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
VIL1 / Villin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (VIL1/1314) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
VIL1 / Villin Mouse anti-Human Monoclonal (VIL1/1325) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
VIL1 / Villin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (VIL1/1325) Antibody
Human
Flo, IF, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
VIL1 / Villin Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Horse, Orangutan, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Cancer Pathology
Cancer
VIL1 / Villin Mouse anti-Human Recombinant Monoclonal (aa179-311) (rVIL1/1325) Antibody
Human
IHC-P
Unconjugated
100 µg/$485
Cancer Pathology
Cancer
VIL1 / Villin Rabbit anti-Human Recombinant Monoclonal (aa179-311) (VIL1/2310R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
VIL1 / Villin Mouse anti-Human Monoclonal (5E3B2) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
VIL1 / Villin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
VIL1 / Villin Mouse anti-Human Monoclonal (aa1-188) (UMAB230) Antibody
Human
IHC, PMA
Unconjugated
100 µl/$493
VIL1 / Villin Mouse anti-Human Monoclonal (aa1-188) (Carrier-free) (UMAB230) Antibody
Human
IHC, PMA
Unconjugated, Carrier-free
100 µg/$539
VIL1 / Villin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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