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CRFR1 / CRHR1
corticotropin releasing hormone receptor 1
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
| Gene Name: | corticotropin releasing hormone receptor 1 |
| Family/Subfamily: | GPCR , Corticotropin releasing factor |
| Synonyms: | CRHR1, CRF-R-1, CRFR, CRHR1f, Crf receptor 1, CRH-R1, CRF-R, CRF1, CRFR-1, Crf receptor type 1, Crf receptor type 1, Crf type 1, CRF-R1, Crf1 receptor, CRFR1, CRH-R-1, CRH-R1h, CRHR, CRHR1L |
| Target Sequences: | NM_004382 P34998 P34998 |
Publications (2)
1
Does the corticotropin-releasing hormone system play a role in the pathogenesis of lichen planus?. Cemil BC, Yilmazer D, Atas H, Cengiz FP, Canpolat F, Alper M, Gonul M. Postepy dermatologii i alergologii. 2017 August;34:322-327. (Human)
[Full Text Article]
[PubMed:28951706]
[PMC:PMC5560179]
Related Antibodies: LS-A6603.
2
Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease. Isabel Weigand, Lisanne Knobloch, Jörg Flitsch, Wolfgang Saeger, Camelia M Monoranu, Kerstin Höfner, Sabine Herterich, Roman Rotermund, Cristina L Ronchi, Michael Buchfelder, Markus Glatzel, Christian Hagel, Martin Fassnacht, Timo Deutschbein, Silviu Sbiera. The Journal of clinical endocrinology and metabolism. 2019 July;104:2535-2546. [Full Text Article]
[PubMed:30844069]
Related Antibodies: LS-A6687.
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Neuroscience
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$395
Neuroscience
Fast Shipping
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$395
Neuroscience
Fast Shipping
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, IHC-P
Unconjugated
50 µg/$440
CRFR1 / CRHR1 Goat anti-Human Polyclonal (aa250-263) Antibody
Chicken, Zebrafish, Pig, Horse, Bat, Sheep, Bovine, Mouse, Dog, Hamster, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$375
CRFR1 / CRHR1 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$896
CRFR1 / CRHR1 Goat anti-Human Polyclonal (aa107-117) Antibody
Mouse, Rat, Hamster, Human, Monkey
ICC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
Neuroscience
Fast Shipping
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Dog, Sheep, Bovine, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$395
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa263-312) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa75-124) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$305; 100 µl/$357
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal (aa88-119) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
CRFR1 / CRHR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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