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CD144 / CDH5 / VE Cadherin
cadherin 5, type 2 (vascular endothelium)
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
| Gene Name: | cadherin 5, type 2 (vascular endothelium) |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | CDH5, 7B4, 7B4 antigen, CD144, Cadherin-5, Endothelial-specific cadherin, Vascular endothelial cadherin, VE-cadherin, VEC, CD144 antigen, VE Cadherin |
| Target Sequences: | NM_001795 NP_001786.2 P33151 |
Publications (7)
1
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Long L, Ormiston ML, Yang X, Southwood M, Gräf S, Machado RD, Mueller M, Kinzel B, Yung LM, Wilkinson JM, Moore SD, Drake KM, Aldred MA, Yu PB, Upton PD, Morrell NW. Nature medicine. 2015 21:777-85. (Func; Mouse)
[Full Text Article]
[PubMed:26076038]
[PMC:PMC4496295]
2
Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. PloS one. 2015 10:e0133874. (ICC, WB; Human, Rat)
[Full Text Article]
[PubMed:26207818]
[PMC:PMC4514746]
3
A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter. Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T. PLoS genetics. 2015 11:e1005581. (IHC, IF; Human)
[Full Text Article]
[PubMed:26539716]
[PMC:PMC4634957]
Related Antibodies: LS-B3780.
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CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (16B1) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (PE) (16B1) Antibody
Human
Flo
PE Conjugated
100 µg/$547
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (aa766-784) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (pTyr731) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$328; 100 µl/$419
CD144 / CDH5 / VE Cadherin Rat anti-Mouse Monoclonal (BV14) Antibody
Mouse
IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$350; 500 µg/$529
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (aa48-333) (OTI1F4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (pTyr731) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$391
CD144 / CDH5 / VE Cadherin Rat anti-Mouse Monoclonal (eBioBV13 (BV13)) Antibody
Mouse, Human
Flo, Func, IHC-Fr, IP, WB
Unconjugated
50 µg/$286
Sandwich
96-Well Microplate
Mouse
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (16B1) Antibody
Mouse, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$388
Sandwich
96-Well Strip Plate
Pig
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$573
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (aa697-746) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (BV9) Antibody
Human
Flo, Func, IF, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$554
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal Antibody
Chicken, Bovine, Mouse, Human
IHC, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Microplate
Rat
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$528
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (aa29-223) (3D5C7) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (aa29-223) (3D5C7) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (pTyr731) Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CD144 / CDH5 / VE Cadherin Rabbit anti-Mouse Polyclonal (aa251-426) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553
CD144 / CDH5 / VE Cadherin Rabbit anti-Mouse Monoclonal (APC) (201) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$263; 100 Tests/$323
CD144 / CDH5 / VE Cadherin Rabbit anti-Human Polyclonal (aa279-328) Antibody
Human
WB
Unconjugated
100 µl/$424
CD144 / CDH5 / VE Cadherin Mouse anti-Human Monoclonal (GF1) Antibody
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$854
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