C5b-9 Terminal Complement Complex / TCC

The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogenic bacterial cells as a result of the activation of the host's alternative pathway, classical pathway, or lectin pathway of the complement system, and it is one of the effector proteins of the immune system. The membrane-attack complex (MAC) forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-6-7 complex. The C5b-6-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-6-7-8 complex. C5b-6-7-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}.

C5b-9 Terminal Complement Complex / TCC Target Details

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Antibodies (8)

ELISA Kits (5)

Type

Primary (8)

Sandwich (4)

Sandwich CLIA (1)

Target

C5b-9 Terminal Complement Complex / TCC (13)

Reactivity

Human (8)

Mouse (2)

Rat (3)

Horse (2)

Pig (2)

Application

IHC (7)

IHC-Fr (4)

IHC-P (3)

WB (6)

Flo (3)

ELISA (5)

Func (1)

IF (3)

RIA (1)

Host

mouse (8)

Isotype

IgG1 (1)

IgG2a (3)

IgG2b (4)

Clonality

monoclonal mc (8)

Clone

2A1 (1)

3R2/0 (1)

aE11 (2)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (2)

Biotin Conjugated (1)

FITC Conjugated (2)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (3)

Publications

No (12)

Yes (1)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (5)

Serum (5)

Tissue Homogenates (3)

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C5b-9 Terminal Complement Complex / TCC Antibody (clone 3R2/0) LS-C58185

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (3R2/0) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

0.1 mg/$847

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C5b-9 Terminal Complement Complex / TCC Antibody (clone 2A1) LS-C210281

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Rat Monoclonal (2A1) Antibody

Reactivity:

Rat

Applications:

Flo, IF, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$589

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C5b-9 Terminal Complement Complex / TCC Antibody (HRP) LS-C549571

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$1,288

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C5b-9 Terminal Complement Complex / TCC Antibody (Biotin) LS-C529480

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,288

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C5b-9 Terminal Complement Complex / TCC Antibody (FITC) LS-C539399

(4.0) Rating

(1) Publication(s)

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$1,288

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C5b-9 Terminal Complement Complex / TCC Antibody (PE) LS-C657544

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

100 µl/$1,288

• HRP
• Biotin
• FITC
• PE

• HRP
• Biotin
• FITC
• More...
  • PE

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C5b-9 Terminal Complement Complex / TCC Antibody (clone aE11, FITC) LS-C210266

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (FITC) (aE11) Antibody

Reactivity:

Pig, Horse, Human

Applications:

IF, IHC-Fr, IHC-P

Format:

FITC Conjugated

Price:

100 µg/$738

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Mouse C5b-9 Terminal Complement Complex / TCC (Sandwich ELISA) ELISA Kit - LS-F56557

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

12.5 - 800 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat C5b-9 Terminal Complement Complex / TCC (Sandwich ELISA) ELISA Kit - LS-F21613

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse C5b-9 Terminal Complement Complex / TCC (Sandwich ELISA) ELISA Kit - LS-F22262

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$771

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Human C5b-9 Terminal Complement Complex / TCC (CLIA) ELISA Kit - LS-F30076

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

15.63 - 1000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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C5b-9 Terminal Complement Complex / TCC Antibody (clone aE11) LS-C663067

Antibody:

C5b-9 Terminal Complement Complex / TCC Mouse anti-Human Monoclonal (aE11) Antibody

Reactivity:

Pig, Horse, Human

Applications:

Flo, Func, IF, IHC, IHC-Fr, IHC-P, RIA

Format:

Unconjugated

Price:

100 µg/$652

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Rat C5b-9 Terminal Complement Complex / TCC (Sandwich ELISA) ELISA Kit - LS-F54019

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,041

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