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| Catalog Number | Size | Price |
|---|---|---|
| LS-C389189-100 | 100 µg | $575 |
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Polyclonal Rabbit anti‑Human AML1 / RUNX1 Antibody (aa227‑257, IHC, WB) LS‑C389189
Polyclonal Rabbit anti‑Human AML1 / RUNX1 Antibody (aa227‑257, IHC, WB) LS‑C389189
Antibody:
AML1 / RUNX1 Rabbit anti-Human Polyclonal (aa227-257) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
AML1 / RUNX1 Rabbit anti-Human Polyclonal (aa227-257) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified
Specifications
Description
RUNX1 antibody LS-C389189 is an unconjugated rabbit polyclonal antibody to RUNX1 (AML1) (aa227-257) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB.
Target
Human AML1 / RUNX1
Synonyms
RUNX1 | AMLCR1 | Aml1 oncogene | AML1 | AML1-EVI-1 | CBF-alpha-2 | CBFA2 | Acute myeloid leukemia 1 | EVI-1 | PEBP2A2 | PEA2-alpha B | AML1-EVI-1 fusion protein | Oncogene AML-1 | PEBP2-alpha B | PEBP2aB
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Sheep
(tested or 100% immunogen sequence identity)
Predicted
Guinea pig, Chicken (at least 90% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from the middle region of human RUNX1 (ELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFN). Percent identity by BLAST analysis: Human, Mouse, Rat, Ferret, Sheep, Bovine, Hamster, Rabbit, Horse, Pig, Zebra finch, Dog (100%); Chicken (97%); Opossum, Guinea pig, Platypus, Lizard (90%); Elephant (84%).
Epitope
aa227-257
Specificity
Human AML1 / RUNX1
Applications
- IHC
- IHC - Paraffin (0.5 - 1 µg/ml)
- Western blot (0.5 - 1 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Runt-related transcription factor 1, also known as AML1 or CBFA2, is a protein that in humans is encoded by the RUNX1 gene. It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called Core binding factor alpha (CBFa). RUNX1 is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. RUNX proteins form a heterodimeric complex with CBFb which confers increased DNA binding and stability to the complex. Chromosomal translocations involving the gene are associated with several types of leukemia including M2 AML. Mutations are implicated in cases of breast cancer.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About AML1 / RUNX1
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Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human, Chimpanzee, Orangutan, Monkey, Mouse, Rat, Bovine, Hamster, Horse
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
