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Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.
Gene Name: | ventral anterior homeobox 2 |
Synonyms: | VAX2, DRES93, Ventral anterior homeobox 2 |
Target Sequences: | Y17791 CAB56166.1 Q9UIW0 |
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