SIGLEC12

Sialic acid binding Ig-like lectin 12

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.

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Proteins (14)

Type

Over-Expression Lysate (4)

Recombinant (10)

Target

SIGLEC12 (14)

Publications

No (14)

Tag

GST (1)

GST, N-terminus (2)

His (2)

His-S (1)

Myc-DDK (Flag) (8)

Species

Human (11)

Mouse (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (6)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human SIGLEC12 Protein (Recombinant His) (aa22-218) - LS-G13535

Source:

E. coli

Tag:

His

Molecular Weight:

23.7 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Human SIGLEC12 Protein (Recombinant GST) (Full Length) - LS-G35946

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

91.4 kDa

Price:

2 µg/$439

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Human SIGLEC12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92640

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.1 kDa

Price:

20 µg/$215

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Human SIGLEC12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92642

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

20 µg/$150

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Human SIGLEC12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73790

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.1 kDa

Price:

20 µg/$1,107

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Human SIGLEC12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73791

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14.3 kDa

Price:

20 µg/$1,107

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Human SIGLEC12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73792

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

14.3 kDa

Price:

20 µg/$1,107

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Human SIGLEC12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72499

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

20 µg/$1,107

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Human SIGLEC12 Protein (Recombinant GST, N-terminus) (aa153-251) - LS-G63450

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human SIGLEC12 Protein (Recombinant GST, N-terminus) (aa503-595) - LS-G63451

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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SIGLEC12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108057

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

100 µg/$494

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SIGLEC12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108286

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.1 kDa

Price:

100 µg/$710

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Mouse SIGLEC12 Protein (Recombinant His-S) (aa27-141) - LS-G13538

Source:

E. coli

Tag:

His-S

Molecular Weight:

19.5 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human SIGLEC12 Protein (Recombinant His) (aa317-512) - LS-G13536

Source:

E. coli

Tag:

His

Molecular Weight:

22.1 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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