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SHSF1 / SHFM1
26S proteasome complex subunit SEM1
Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component <br>of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and <br>either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent <br>ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 <br>participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear <br>periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus <br>transcription-associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
| Gene Name: | 26S proteasome complex subunit SEM1 |
| Synonyms: | SEM1, DSS1, SHSF1, SHFD1, Shfdg1, SHFM1 |
| Target Sequences: | NM_006304 NP_006295.1 P60896 |
Publications (1)
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