RING1

ring finger protein 1

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

RING1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RING1 Protein (Recombinant GST) (Full Length) - LS-G30177

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RING1 Protein (Recombinant GST, N-terminus) (aa81-170) - LS-G59916

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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RING1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99906

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

100 µg/$494

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Human RING1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66896

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

20 µg/$1,107

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Human RING1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78672

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.2 kDa

Price:

20 µg/$150

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