PSMC2 / RPT1

proteasome (prosome, macropain) 26S subunit, ATPase, 2

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PSMC2 / RPT1 (4)

Publications

No (4)

Tag

GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PSMC2 / RPT1 Protein (Recombinant GST) (Full Length) - LS-G29986

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.37 kDa

Price:

10 µg/$479; 25 µg/$670

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PSMC2 / RPT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99876

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

100 µg/$494

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Human PSMC2 / RPT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74019

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.5 kDa

Price:

20 µg/$150

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Human PSMC2 / RPT1 Protein (Recombinant His-T7) (aa1-433) - LS-G15724

Source:

E. coli

Tag:

His-T7

Molecular Weight:

52.5 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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