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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 7 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMB7, Proteasome catalytic subunit 2, Macropain chain Z, Proteasome subunit Z, Proteasome subunit alpha, Proteasome subunit beta type-7 |
Target Sequences: | NM_002799 NP_002790.1 Q99436 |
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