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Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Gene Name: | pre-mRNA processing factor 8 |
Synonyms: | PRPF8, Apoptosis-regulated protein 1, p220, PRP8 homolog, PRP8, PRPC8, RP13, Splicing factor Prp8, Apoptosis-regulated protein 2, HPRP8 |
Target Sequences: | NM_006445 NP_006436.3 Q6P2Q9 |
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