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PRPF4 is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | pre-mRNA processing factor 4 |
Synonyms: | PRPF4, HPRP4, PRP4, PRP4 homolog, Prp4p, U4/U6 snRNP 60 kDa protein, PRP4/STK/WD splicing factor, HPRP4P, WD splicing factor Prp4 |
Target Sequences: | NM_004697 NP_004688.2 O43172 |
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