PRKCI / PKC Iota

protein kinase C, iota

Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI3K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis.

☰ Filters

Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

PRKCI / PKC Iota (7)

Publications

No (7)

Tag

GST (2)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

Human PRKCI / PKC Iota Protein (Recombinant GST) (Full Length) - LS-G29905

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

90.31 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human PRKCI / PKC Iota Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66710

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

20 µg/$1,107

Select

Human PRKCI / PKC Iota Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59731

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PRKCI / PKC Iota Protein (Recombinant GST) (Met10-Val596) - LS-G97775

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

93.5 kDa

Price:

50 µg/$561

Select

Human PRKCI / PKC Iota Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78339

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

20 µg/$150

Select

PRKCI / PKC Iota Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99848

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.1 kDa

Price:

100 µg/$494

Select

Human PRKCI / PKC Iota Protein (Recombinant His-T7) (aa375-596) - LS-G12249

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.1 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

Viewing 1-7 of 7 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.