PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

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Products

Proteins (15)

Type

Over-Expression Lysate (8)

Recombinant (7)

Target

PRKAR1A (15)

Publications

No (15)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (11)

Species

Human (11)

Source

293T Cells (4)

HEK 293 Cells (7)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (2)

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Human PRKAR1A Protein (Recombinant 6His, C-terminus) (Glu2-Val381) - LS-G39993

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

44kD

Price:

10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203

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Human PRKAR1A Protein (Recombinant GST) (Full Length) - LS-G29899

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRKAR1A Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59724

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81357

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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Human PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81358

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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Human PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81359

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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Human PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81360

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99847

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

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Human PRKAR1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68063

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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Human PRKAR1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68062

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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Human PRKAR1A Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68064

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G127785

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

Select

PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102736

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

Select

PRKAR1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102738

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

Select

Human PRKAR1A Protein (Recombinant 6His, C-terminus) (Glu2-Val381) - LS-G138614

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

44.0 kDa

Price:

10 µg/$248; 50 µg/$288

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