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PRG2 / Proteoglycan 2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

PRG2 / Proteoglycan 2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Synonyms: PRG2, BMPG, Bone marrow proteoglycan, Bone-marrow proteoglycan, Eosinophil major basic protein, MBP1, Natural killer cell activator, Proteoglycan 2, Proteoglycan 2 preproprotein
Target Sequences: NM_002728 NP_002719.3 P13727

Publications (1)

1
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation. Mackenzie E Coden, Lucas F Loffredo, Matthew T Walker, Brian M Jeong, Kiwon Nam, Bruce S Bochner, Hiam Abdala-Valencia, Sergejs Berdnikovs. Journal of immunology (Baltimore, Md. : 1950). 2020 January;204:438-448. [Full Text Article] [PubMed:31818982]

☰ Filters
Antibodies (46)
Proteins (10)
ELISA Kits (7)
Custom (3)
Over-Expression Lysate (2)
Primary (46)
Recombinant (8)
Sandwich (3)
Sandwich CLIA (1)
PRG2 / Proteoglycan 2 (63)
Human (37)
Mouse (13)
Rat (3)
Bovine (1)
IHC (6)
IHC-Fr (2)
IHC-P (3)
WB (40)
ELISA (7)
ICC (8)
IF (2)
IP (8)
Peptide-ELISA (1)
rabbit (21)
mouse (25)
IgG (24)
IgG1 (6)
IgG2a (2)
monoclonal mc (25)
polyclonal pc (21)
BMK-13 (2)
OTI10D10 (2)
OTI1C12 (2)
OTI2F11 (2)
96-Well Strip Plate (7)
APC (3)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (6)
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aa80-219 (2)
aa100-215 (1)
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6His, C-terminus (2)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
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His-MBP (1)
Myc-DDK (Flag) (2)
Human (6)
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293T Cells (1)
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HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
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PRG2 / Proteoglycan 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
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Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
24.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (BMK-13) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 mg/$505
PRG2 / Proteoglycan 2 Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PRG2 / Proteoglycan 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ICC, IP, WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ICC, IP, WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (Cy3) Antibody
Human
ICC, IP, WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (PE) Antibody
Human
ICC, IP, WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (APC, Cy7) Antibody
Human
ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (APC) Antibody
Human
ICC, IP, WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
54.9 - 40000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
PRG2 / Proteoglycan 2 Antibody
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PRG2 / Proteoglycan 2 Rabbit anti-Mouse Polyclonal Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
PRG2 / Proteoglycan 2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer at dilution of 1:100
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PRG2 / Proteoglycan 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (FITC) Antibody
Human
WB
FITC Conjugated
200 µl/$379
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (Azide-free) (BMK-13) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated, Azide-free
100 µg/$896
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
PRG2 / Proteoglycan 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.23 kDa
20 µg/$150
PRG2 / Proteoglycan 2 Protein - Recombinant Major Basic Protein By SDS-PAGE
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E. coli
His-GST
51.4 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
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PRG2 / Proteoglycan 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$406
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PRG2 / Proteoglycan 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$351
PRG2 / Proteoglycan 2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY PRG2. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRG2. (1:500)
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (aa17-222) (Carrier-free) (OTI10D10) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
PRG2 / Proteoglycan 2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY PRG2. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRG2. (1:500)
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (aa17-222) (Carrier-free) (OTI2F11) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
PRG2 / Proteoglycan 2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY PRG2. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PRG2. (1:500)
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PRG2 / Proteoglycan 2 Mouse anti-Human Monoclonal (aa17-222) (Carrier-free) (OTI1C12) Antibody
Human
WB
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-25 of 63 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).