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PHOX2B
paired-like homeobox 2b
Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.
| Gene Name: | paired-like homeobox 2b |
| Synonyms: | PHOX2B, PHOX2B homeodomain protein, PMX2B, Neuroblastoma Phox, Paired-like homeobox 2b, NBLST2, NBPhox, Paired mesoderm homeobox 2b |
| Target Sequences: | NM_003924 NP_003915.2 Q99453 |
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