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PH4 / P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
| Gene Name: | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| Synonyms: | P4HTM, EGLN4, HIF-PH4, HIF-prolyl hydroxylase 4, p4H with transmembrane domain, PH-4, p4H-TM, HIFPH4, HPH-4, p4HTM, PH4, PHD4, Proline 4-hydroxylase |
| Target Sequences: | NM_017732 Q9NXG6 Q9NXG6 |
Publications (1)
1
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Cancer research. 2010 70:357-66.
[PubMed:20028863]
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Products
Antibodies
(17)
Type
Primary
(17)
Target
PH4 / P4HTM
(17)
Reactivity
Human
(17)
Mouse
(8)
Rat
(7)
Bat
(6)
Bovine
(6)
Chimpanzee
(6)
Dog
(6)
Gibbon
(6)
Guinea pig
(3)
Horse
(3)
Monkey
(6)
Pig
(6)
Rabbit
(6)
Application
IHC
(1)
WB
(11)
ELISA
(4)
IF
(3)
Peptide-ELISA
(1)
Host
rabbit
(17)
Isotype
IgG
(13)
Clonality
polyclonal pc
(17)
Format
Biotin Conjugated
(3)
FITC Conjugated
(3)
HRP Conjugated
(3)
Unconjugated
(8)
Epitope
aa215-264
(4)
aa323-372
(4)
aa82-563
(4)
aa450-C-term
(1)
Publications
No
(17)
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 100 µl/$389
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) Antibody
Human
WB
Unconjugated
100 µl/$424
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) Antibody
Human
WB
Unconjugated
100 µl/$424
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa450-C-term) Antibody
Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
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