PDZK1

PDZ domain containing 1

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PDZK1 (6)

Publications

No (6)

Tag

GST (1)

His (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human PDZK1 Protein (Recombinant His) - LS-G2290

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human PDZK1 Protein (Recombinant GST) (Full Length) - LS-G29679

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82.83 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PDZK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80199

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$150

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PDZK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99810

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

100 µg/$494

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Human PDZK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67576

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.9 kDa

Price:

20 µg/$1,107

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Human PDZK1 Protein (Recombinant His) (Full Length) - LS-G21735

Source:

E. coli

Tag:

His

Molecular Weight:

61.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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