PDPK1 / PDK1

3-phosphoinositide dependent protein kinase-1

Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca2+ entry and Ca2+-activated K+ channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF-kappa-B activation in macrophages. Isoform 3 is catalytically inactive.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

PDPK1 / PDK1 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (2)

His (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (8)

Source

293T Cells (2)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (3)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human PDPK1 / PDK1 Protein (Recombinant GST) (Full Length) - LS-G29680

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.82 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PDPK1 / PDK1 Protein (Recombinant GST, N-terminus) (aa457-556) - LS-G59557

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human PDPK1 / PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80268

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

20 µg/$150

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Human PDPK1 / PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80269

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$150

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PDPK1 / PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99809

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

63 kDa

Price:

100 µg/$494

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Human PDPK1 / PDK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67606

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$1,107

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Human PDPK1 / PDK1 Protein (Recombinant GST, N-terminus) (aa253-348) - LS-G64564

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PDPK1 / PDK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109300

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

100 µg/$494

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Human PDPK1 / PDK1 Protein (Recombinant His) (Ser29-Ala436) - LS-G97762

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.6 kDa

Price:

50 µg/$793

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Human PDPK1 / PDK1 Protein (Recombinant His-T7) (aa83-338) - LS-G14857

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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