PDK4

pyruvate dehydrogenase kinase, isozyme 4

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

PDK4 (9)

Publications

No (9)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His/GST,N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (3)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human PDK4 Protein (Recombinant GST) (Full Length) - LS-G29675

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.95 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse PDK4 Protein (Recombinant 6His, N-terminus) (aa138-368) - LS-G56449

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human PDK4 Protein (Recombinant GST, N-terminus) (aa181-280) - LS-G59555

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PDK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66788

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.3 kDa

Price:

20 µg/$1,107

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PDK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99808

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.3 kDa

Price:

100 µg/$494

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Human PDK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78503

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.3 kDa

Price:

20 µg/$150

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Mouse PDK4 Protein (Recombinant His/GST,N-terminus) (Met1-Val412) - LS-G140012

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

74.4 kDa

Price:

50 µg/$707

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Human PDK4 Protein (Recombinant His-T7) (aa73-316) - LS-G13142

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.4 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse PDK4 Protein (Recombinant His-T7) (aa117-387) - LS-G13144

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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